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From the Human Cortical Physiology Section (Drs. Boroojerdi and Cohen), Cognitive Neuroscience Section (Drs. Wharton and Grafman, and M. Phipps), and Biostatistics Branch (Dr. Kopylev), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.
Address correspondence and reprint requests to Dr. Jordan Grafman, Cognitive Neuroscience Section, NINDS, NIH, Building 10, Room 5C205, MSC 1440, Bethesda, MD 20892-1440; e-mail: grafmanj{at}ninds.nih.gov; or Dr. Leonardo G. Cohen, Human Cortical Physiology Section, NINDS, NIH, Building 10, Room 5N234, MSC 1430, Bethesda, Maryland 20892-1430; e-mail: cohenl@ninds.nih.gov
The authors utilized repetitive transcranial magnetic stimulation (rTMS) in 16 normal volunteers to investigate the role of the left dorsolateral prefrontal cortex (PFC) in analogic reasoning. rTMS over the left and right PFC, over the left motor cortex, and sham stimulation over the left PFC were administered during memory and analogic reasoning conditions. rTMS over the left PFC led to a significant reduction in response times only in the analogy condition without affecting accuracy. These results indicate that the left PFC is relevant for analogic reasoning and that rTMS applied to the PFC can speed up solution time.
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