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Neurology 2001;56:529-530
© 2001 American Academy of Neurology
Brief Communications

Antibodies to brain antigens following stroke

N.M. Bornstein, MD;, B. Aronovich, MD;, A.D. Korczyn, MD, MSc;, S. Shavit, MSc;, D.M. Michaelson, PhD; and J. Chapman, MD, PhD

From the Stroke Unit (Drs. Bornstein and Aronovich) and Neuroimmunology Clinic (Dr. Chapman), Department of Neurology (Dr. Korczyn), Tel Aviv Sourasky Medical Center; Department of Physiology and Pharmacology (Drs. Korczyn and Chapman, and S. Shavit), Sackler Faculty of Medicine; and Department of Neurobiochemistry (Dr. Michaelson), Wise Faculty of Medicine, Tel Aviv University, Israel.

Address correspondence and reprint requests to Dr. Joab Chapman, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel; e-mail: jchapman{at}post.tau.ac.il

Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, within 48 hours, and 1, 3, and 6 months later. The mean levels of anti-NF antibodies were elevated compared with baseline at 1, 3, and 6, months (p = 0.012, 0.002, and 0.003 by paired t-test). Anti-CL levels did not change significantly.




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