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Neurology 2001;56:537-539
© 2001 American Academy of Neurology
Brief Communications

Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria

Katherine A. Knudsen, BA;, Jonathan Rosand, MD;, Diane Karluk, MD; and Steven M. Greenberg, MD, PhD

From the Clinical Trials Unit, Department of Neurology (K. Knudsen and Drs. Rosand and Greenberg) and C.S. Kubik Laboratory for Neuropathology (Dr. Karluk), Massachusetts General Hospital and Harvard Medical School, Boston.

Address correspondence and reprint requests to Dr. Steven M. Greenberg, Neurology Clinical Trials Unit, Wang ACC 836, Massachusetts General Hospital, Boston, MA 02114; e-mail greenberg{at}helix.mgh.harvard.edu

The authors performed clinical–pathologic correlation to assess the validity of the Boston diagnostic criteria for cerebral amyloid angiopathy (CAA). Thirteen subjects were diagnosed clinically with probable CAA from among 39 patients with available pathologic tissue in a prospective cohort of subjects aged >=55 years with primary lobar hemorrhage. All 13 individuals were confirmed neuropathologically as having CAA. This small pathologic series indicates that the diagnosis of probable CAA can be made during life with high accuracy.




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