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From the Department of Neurology (Drs. Volkmann, Allert, Weiss, and Freund), Heinrich-Heine-University, Düsseldorf; Department of Stereotaxy and Functional Neurosurgery (Dr. Sturm), University of Cologne; and IME (Dr. Weiss), Forschungszentrum Jülich, Germany
Address correspondence and reprint requests to Dr. J. Volkmann, Department of Neurology, Heinrich-Heine-University, Moorenstr. 5, D-40225 Düsseldorf, Germany; e-mail: volkmann{at}neurologie.uni-duesseldorf.de
The authors retrospectively compared 1-year results of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN; n = 16) and internal pallidum (GPi) (n = 11) in advanced PD and found about equal improvements in "off" period motor symptoms, dyskinesias, and fluctuations. STN stimulation reduced medication requirements by 65% and required significantly less electrical power. These advantages contrasted with a need for more intensive postoperative monitoring and a higher incidence of adverse events related to levodopa withdrawal.
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