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From the Departments of Neurology (Drs. Hillis, Mirski, and Wityk), Radiology (Drs. Barker and Beauchamp), and Anesthesiology and Critical Care Medicine (Drs. Winters and Mirski), Johns Hopkins University School of Medicine; and the Department of Cognitive Science (Dr. Hillis), Johns Hopkins University, Baltimore, MD.
Address correspondence and reprint requests to Dr. Argye E. Hillis, Department of Neurology, Johns Hopkins Hospital, Meyer 5-185, 600 N. Wolfe Street, Baltimore, MD 21287; e-mail: argye{at}JHMI.edu
Longitudinal clinical and imaging data from a patient who sustained a left frontal-temporal stroke with hypoperfusion of the adjacent Wernicke’s area are reported. His language deficits were partially ameliorated by pharmacologically increasing his blood pressure, and were exacerbated when blood pressure dropped. There was a striking temporal and statistical correlation between mean arterial pressure and language accuracy. MR perfusion imaging showed that language gains were accompanied by improved perfusion of Wernicke’s area when mean arterial pressure was increased.
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