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Neurology 2001;56:678-681
© 2001 American Academy of Neurology
Brief Communications

Chronic encephalitis and temporal lobe epilepsy: A variant of Rasmussen’s syndrome?

M.J. Hennessy, MRCPI;, M. Koutroumanidis, MD;, A.F. Dean, PhD;, J. Jarosz, FRCR;, R.D.C. Elwes, MD;, C.D. Binnie, MD; and C.E. Polkey, MD

From the Departments of Clinical Neurophysiology (Drs. Hennessy, Koutroumanidis, Elwes, and Binnie), Neuroimaging (Dr. Jarosz), and Neurosurgery (Dr. Polkey), Kings College Hospital; and Department of Neuropathology (Dr. Dean), Institute of Psychiatry London, UK.

Address correspondence and reprint requests to Dr. M. Koutroumanidis, Department of Clinical Neurophysiology, Mapother House, Kings College Hospital, Denmark Hill, London SE5 9RS, UK; e-mail: michaliskou{at}hotmail.com

The authors report two adult patients with chronic temporal lobe epilepsy and pathologic features consistent with Rasmussen’s encephalitis. Although seizures persisted after temporal lobe surgery no progressive cognitive or neurologic deficit has emerged. Prominent auditory auras in each suggested a persisting epileptogenic focus in the superior temporal gyrus. The current findings expand the clinical spectrum of Rasmussen’s encephalitis and suggest that chronic nonprogressive encephalitis may serve as the pathologic substrate of medically intractable temporal lobe epilepsy.




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