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From the Departments of Clinical Neurophysiology (Drs. Hennessy, Koutroumanidis, Elwes, and Binnie), Neuroimaging (Dr. Jarosz), and Neurosurgery (Dr. Polkey), Kings College Hospital; and Department of Neuropathology (Dr. Dean), Institute of Psychiatry London, UK.
Address correspondence and reprint requests to Dr. M. Koutroumanidis, Department of Clinical Neurophysiology, Mapother House, Kings College Hospital, Denmark Hill, London SE5 9RS, UK; e-mail: michaliskou{at}hotmail.com
The authors report two adult patients with chronic temporal lobe epilepsy and pathologic features consistent with Rasmussens encephalitis. Although seizures persisted after temporal lobe surgery no progressive cognitive or neurologic deficit has emerged. Prominent auditory auras in each suggested a persisting epileptogenic focus in the superior temporal gyrus. The current findings expand the clinical spectrum of Rasmussens encephalitis and suggest that chronic nonprogressive encephalitis may serve as the pathologic substrate of medically intractable temporal lobe epilepsy.
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