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Neurology 2001;56:781-783
© 2001 American Academy of Neurology
Brief Communications

Preliminary evidence of widespread morphological variations of the brain in dyslexia

W. E. Brown, BA;, S. Eliez, MD;, V. Menon, PhD;, J. M. Rumsey, PhD;, C. D. White, BA; and A. L. Reiss, MD

From the Stanford Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Behavioral Sciences (Drs. Eliez, Menon, and Reiss and W.E. Brown and C.D. White), Stanford University School of Medicine, CA, and Clinical Neurosciences Branch (Dr. Rumsey), National Institute of Mental Health, Rockville, MD.

Address correspondence and reprint requests to Dr. A.L. Reiss, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., Stanford, CA 94305-5719; e-mail: areiss1{at}leland.stanford.edu

The MR images of 16 men with dyslexia and 14 control subjects were compared using a voxel-based analysis. Evidence of decreases in gray matter in dyslexic subjects, most notably in the left temporal lobe and bilaterally in the temporoparietooccipital juncture, but also in the frontal lobe, caudate, thalamus, and cerebellum, was found. Widely distributed morphologic differences affecting several brain regions may contribute to the deficits associated with dyslexia.




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