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Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

From the Third Department of Internal Medicine (Drs. Michizono, Umehara, Hashiguchi, Arimura, Matsuura, Watanabe, and Osame), Kagoshima University School of Medicine; the Biopharmaceutical Department (Dr. Fujimoto), Fuji Chemical Industries, Ltd., Takaoka; and the Department of Pathology (Dr. Okada), School of Medicine, Keio University, Tokyo, Japan.

Address correspondence and reprint requests to Dr. F. Umehara, the Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan; e-mail: umehara{at}med6 kufm.kagoshima.u-ac.jp

The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.

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