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From the Division of Life Sciences (Dr. Zakzanis), University of Toronto; and Centre for Addiction and Mental Health (Dr. Young), Archway Clinic, Toronto, Ontario, Canada.
Address correspondence and reprint requests to Dr. Konstantine K. Zakzanis, University of Toronto at Scarborough, Division of Life Sciences (Neuroscience), 1265 Military Trail, Toronto, Ontario, M1C 1A4 Canada; e-mail: zakzanis{at}scar.utoronto.ca
To examine the neurotoxic potential of continued MDMA ("Ecstasy") use in humans and its functional consequences over the course of 1 year, 15 MDMA users participated in a longitudinal study in which they completed a brief neuropsychological test battery composed mainly of retrospective and prospective memory tasks. Subjects were abstinent for 2 weeks on initial and 1-year testing. Continued use of MDMA was associated with progressive decline in terms of immediate and delayed recall.
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