Neurology 2001;56:972-974
© 2001 American Academy of Neurology
Brief Communications
Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study
J. D. Pinter, MD;,
W. E. Brown, BA,
S. Eliez, MD;,
J. E. Schmitt, BS;,
G. T. Capone, MD; and
A. L. Reiss, MD
From the Department of Neurology (Dr. Pinter), University of Washington School of Medicine, Seattle; Department of Psychiatry and Behavioral Sciences (W.E. Brown, J.E. Schmitt, and Drs. Eliez and Reiss), Stanford University School of Medicine, Stanford, CA; and Department of Pediatrics (Dr. Capone), Johns Hopkins University School of Medicine, Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD.
Address correspondence and reprint requests to Dr. Joseph D. Pinter, Division of Pediatric Neurology, CH-49, Children’s Hospital & Regional Medical Center, 4800 Sand Point Way, NE, Seattle, WA 98105; e-mail: pinter @u.washington.edu
The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.
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|
|
|
|
|
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