Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pinter, J. D.
Right arrow Articles by Reiss, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pinter, J. D.
Right arrow Articles by Reiss, A. L.
Neurology 2001;56:972-974
© 2001 American Academy of Neurology
Brief Communications

Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study

J. D. Pinter, MD;, W. E. Brown, BA, S. Eliez, MD;, J. E. Schmitt, BS;, G. T. Capone, MD; and A. L. Reiss, MD

From the Department of Neurology (Dr. Pinter), University of Washington School of Medicine, Seattle; Department of Psychiatry and Behavioral Sciences (W.E. Brown, J.E. Schmitt, and Drs. Eliez and Reiss), Stanford University School of Medicine, Stanford, CA; and Department of Pediatrics (Dr. Capone), Johns Hopkins University School of Medicine, Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD.

Address correspondence and reprint requests to Dr. Joseph D. Pinter, Division of Pediatric Neurology, CH-49, Children’s Hospital & Regional Medical Center, 4800 Sand Point Way, NE, Seattle, WA 98105; e-mail: pinter @u.washington.edu

The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. Dierssen, Y. Herault, and X. Estivill
Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome
Physiol Rev, July 1, 2009; 89(3): 887 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Galante, H. Jani, L. Vanes, H. Daniel, E. M.C. Fisher, V. L.J. Tybulewicz, T. V.P. Bliss, and E. Morice
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome
Hum. Mol. Genet., April 15, 2009; 18(8): 1449 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
E. Morice, L. C. Andreae, S. F. Cooke, L. Vanes, E. M.C. Fisher, V. L.J. Tybulewicz, and T. V.P. Bliss
Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome
Learn. Mem., July 14, 2008; 15(7): 492 - 500.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Chakrabarti, Z. Galdzicki, and T. F. Haydar
Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome
J. Neurosci., October 24, 2007; 27(43): 11483 - 11495.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L. E. Olson, R. J. Roper, C. L. Sengstaken, E. A. Peterson, V. Aquino, Z. Galdzicki, R. Siarey, M. Pletnikov, T. H. Moran, and R. H. Reeves
Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice
Hum. Mol. Genet., April 1, 2007; 16(7): 774 - 782.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Kleschevnikov, P. V. Belichenko, A. J. Villar, C. J. Epstein, R. C. Malenka, and W. C. Mobley
Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome
J. Neurosci., September 15, 2004; 24(37): 8153 - 8160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. D. Bigler, D. F. Tate, E. S. Neeley, L. J. Wolfson, M. J. Miller, S. A. Rice, H. Cleavinger, C. Anderson, H. Coon, S. Ozonoff, et al.
Temporal Lobe, Autism, and Macrocephaly
AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 2066 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
S. J. Teipel, M. B. Schapiro, G. E. Alexander, J. S. Krasuski, B. Horwitz, C. Hoehne, H.-J. Moller, S. I. Rapoport, and H. Hampel
Relation of Corpus Callosum and Hippocampal Size to Age in Nondemented Adults With Down's Syndrome
Am J Psychiatry, October 1, 2003; 160(10): 1870 - 1878.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by AAN Enterprises, Inc.