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Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation

From the Departments of Neurology (Drs. Padovan, Sostak, and Straube) and Neuropathology (Dr. Bise), Ludwig Maximilians University, Munich, and Department of Hematology and Oncology, University of Regensburg (Drs. Gerbitz and Holler), Germany; and Department of Medicine, University of Michigan Medical School and University of Michigan Cancer Center (Dr. Ferrara), Ann Arbor.

Address correspondence and reprint requests to Dr. C.S. Padovan, Department of Neurology, Ludwig Maximilians University, 81366 Munich, Germany; e-mail: padovan{at}brain.nefo.med.uni-muenchen.de

Neurologic manifestation of graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT) has until now been limited to rare neuromuscular syndromes. Investigating cerebral findings using a murine BMT model, the authors found parenchymal lymphocytic inflammation, microglia activation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebral involvement during GvHD may be a new neurologic complication after BMT.

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