| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurology (Dr. Yao and S. Sriram) and Pathology (Drs. Stratton and Mitchell), Vanderbilt University School of Medicine, Nashville, TN.
Address correspondence and reprint requests to Subramaniam Sriram, Multiple Sclerosis Research Laboratory, 1222H Vanderbilt Stallworth Rehabilitation Hospital, 2201 Capers Avenue, Nashville, TN 37212; e-mail: Srirams{at}ctrvax.vanderbilt.edu
BACKGROUND: Considerable evidence suggests the role of an infectious agent in MS. The presence of Chlamydophila pneumoniae in CSF from patients with MS was shown earlier; to further examine this association the reactivity of the oligoclonal antibody response in the CSF of patients with MS to C pneumoniae antigens was determined and compared with other antigens.
METHODS: Seventeen patients with MS and 14 control subjects with other neurologic disease were studied. Affinity-driven immunoblot studies and solid-phase adsorption of CSF oligoclonal bands by elementary body antigens of C pneumoniae, viral antigens (measles and herpes simplex virus-1), bacterial antigen (Escherichia coli and Staphylococcus aureus), and heat shock protein-60 were performed.
RESULTS: Affinity-driven immunoblot studies demonstrated reactivity of oligoclonal bands in CSF samples from 16 patients with MS against elementary body antigens of C pneumoniae. None of the control subjects showed a prominent reactivity to elementary body antigens of C pneumoniae. In 14 of 17 patients with MS examined, oligoclonal bands were adsorbed either partially or completely from the CSF by elementary body antigens of C pneumoniae, but not by myelin basic protein, heat shock protein-60, or bacterial or viral antigens. In three patients with subacute sclerosing panencephalitis, adsorption of oligoclonal bands was seen with measles virus antigens but not with elementary body antigens of C pneumoniae.
CONCLUSIONS: Oligoclonal bands in CSF of patients with MS include antibodies against Chlamydophila antigens.
This article has been cited by other articles:
|
|
 |
|
  P G Bagos, G Nikolopoulos, and A Ioannidis Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis Multiple Sclerosis, August 1, 2006; 12(4): 397 - 411. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Du, S.-Y. Yao, A. Ljunggren-Rose, and S. Sriram Chlamydia pneumoniae Infection of the Central Nervous System Worsens Experimental Allergic Encephalitis J. Exp. Med., December 16, 2002; 196(12): 1639 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Kaufman, C A Gaydos, S Sriram, J Boman, M L Tondella, and H J Norton Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? Conflicting results Multiple Sclerosis, August 1, 2002; 8(4): 289 - 294. [Abstract] [PDF]
|
|
|
|
 |
|
 Chlamydia and Multiple Sclerosis: Is There an Association? Journal Watch Neurology, August 9, 2001; 2001(809): 7 - 7. [Full Text]
|
|
|
|
 |
|
 T. Derfuss, R. Gurkov, F. Then Bergh, N. Goebels, M. Hartmann, C. Barz, B. Wilske, I. Autenrieth, M. Wick, R. Hohlfeld, et al. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response Brain, July 1, 2001; 124(7): 1325 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Gaydos Chlamydia pneumoniae and its proposed link to multiple sclerosis: To be or not to be? Neurology, May 8, 2001; 56(9): 1126 - 1127. [Full Text] [PDF]
|
|
|
|
|
|
S. Jacobson and A. Cross Association of Chlamydia pneumoniae and multiple sclerosis: Stage two? Neurology, May 8, 2001; 56(9): 1128 - 1129. [Full Text] [PDF]
|
|
|
|
|
|
R. C. Griggs Chlamydia: Conflict and controversy Neurology, May 8, 2001; 56(9): 1130 - 1130. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
