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Neurology 2001;56:1233-1236
© 2001 American Academy of Neurology
Brief Communications

Increased familial risk of cluster headache

M. Leone, MD;, M.B. Russell, MD, PhD, DrMedSci;, A. Rigamonti, MD;, A. Attanasio, MD;, L. Grazzi, MD;, D. D’Amico, MD;, S. Usai, MD; and G. Bussone, MD

From the Carlo Besta National Neurological Institute (Drs. Leone, Rigamonti, Attanasio, Grazzi, D’Amico, Usai, and Bussone), Milan, Italy; and Department of Neurology (Dr. Russell), Copenhagen University Hospital, University of Copenhagen, Denmark.

Address correspondence and reprint requests to Dr. G. Bussone, Carlo Besta National Neurological Institute, via Celoria 11, 20133 Milano, Italy; e-mail: bussone{at}istituto-besta.it

The authors studied the occurrence of cluster headache in the families of 220 Italian patients with cluster headache. A positive family history was found in 20% (44/220) of the families. Compared with the general population, first-degree relatives had a 39-fold significantly increased risk of cluster headache. Second-degree relatives had an eightfold significantly increased risk. The increased familial risk strongly supports the hypothesis that cluster headache has a genetic component in some families.




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