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Neuropathology of Pick’s disease

From the Department of Pathology, Mayo Clinic Jacksonville, FL.

Address correspondence and reprint requests to Dr. Dennis W. Dickson, Neuropathology, Birdsall Building, 317, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: dickson.dennis{at}mayo.edu

The author reviews the gross, microscopic, and biochemical pathology associated with classic Pick’s disease, as defined by Constantinidis’ Type A Pick’s disease. This is contrasted with other Pick’s disease subtypes, including Constantinidis’ Type B (corticobasal degeneration) and Type C (dementia lacking distinctive histology).

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