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Neurology 2001;57:127-130
© 2001 American Academy of Neurology
Brief Communications

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

R. J. Hagerman, MD;, M. Leehey, MD;, W. Heinrichs, MEd;, F. Tassone, PhD;, R. Wilson, PsyD;, J. Hills, PsyD;, J. Grigsby, PhD;, B. Gage, MD; and P. J. Hagerman, MD, PhD

From the M.I.N.D. Institute (Drs. R.J. Hagerman, Tassone, and P.J. Hagerman) and the University of California at Davis Medical Center, Sacramento; Departments of Neurology (Dr. Leehey) and Medicine (Dr. Grigsby), University of Colorado Health Sciences Center, Denver; Fragile X Treatment and Research Center (Drs. Hills and Wilson, and W. Heinrichs), The Children’s Hospital, Denver; Department of Biological Chemistry (Drs. Tassone and P.J. Hagerman), University of California at Davis School of Medicine; and Kaiser Permanente (Dr. Gage), Stockton, CA.

Address correspondence and reprint requests to Dr. Randi Hagerman, M.I.N.D. Institute, UC Davis Medical Center, 4860 Y Street, Suite 3020, Sacramento, CA 95817; e-mail: randi.hagerman{at}ucdmc.ucdavis.edu

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.




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Correspondence:

Read all Correspondence

Adult-onset neurodegeneration in Fragile X syndrome
David G Munoz
Neurology Online, 15 Oct 2001 [Full text]
Reply to Munoz
RJ Hagerman, et al.
Neurology Online, 24 Oct 2001 [Full text]

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