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Neurology 2001;57:149-152
© 2001 American Academy of Neurology
Brief Communications

Myopathy with tubulin-reactive crystalline inclusions

T. H. Vu, MD;, A. P. Hays, MD;, K. Tanji, MD;, D. Younger, MD;, G.G. Gundersen, PhD;, A. Eastwood, PhD;, C. W. Braun, MD;, S. DiMauro, MD; and E. Bonilla, MD

From the H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Disorders and Department of Neurology (Drs. Vu, Bonilla, and DiMauro), and Departments of Pathology (Drs. Hays, Tanji, and Gundersen) and Anatomy & Cell Biology (Dr. Gundersen), Columbia University; Department of Neurology (Dr. Younger), New York University; National Multiple Sclerosis Society (Dr. Eastwood); and the Department of Neurology (Dr. Braun), St. Luke’s–Roosevelt Medical Center, New York, NY.

Address correspondence and reprint requests to: Dr. Euardo Bonilla, Department of Neurology, Columbia University, P&S 5-431, 630 W. 168th Street, New York, NY 10032; e-mail: eb19{at}columbia.edu

A 61-year-old man with muscle aches and persistently elevated serum creatine kinase had aggregates of randomly oriented, rhomboidal or rectangular protein crystalline inclusions in the sarcoplasm of type II fibers. Immunochemical studies showed strong reactivity of the inclusions to tubulin antibodies, suggesting that these unique crystalline inclusions may be a consequence of altered synthesis, processing, or degradation of tubulin.




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