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From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guys, Kings, and St. Thomas School of Medicine; Department of Neurology and the Kings MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. NewsomDavis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guys, Kings and St. Thomas School of Medicine, Kings College Hospital, London, United Kingdom.
Address correspondence and reprint requests to Dr. Rebecca Lyall, Respiratory Muscle Laboratory, Department of Respiratory Medicine, Guys, Kings and St. Thomas School of Medicine, Bessemer Road, London SE5 9PJ, UK; e-mail: rebecca.lyall@ kcl.ac.uk
Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.
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