Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
 Volume 57, Number 10, November 27, 2001
Right arrow Suppl Data
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Witting, N.
Right arrow Articles by Jensen, T. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Witting, N.
Right arrow Articles by Jensen, T. S.
Related Collections
Right arrow All Pain
Right arrow Neuropathic pain
Neurology 2001;57:1817-1824
© 2001 American Academy of Neurology
Articles

Experimental brush-evoked allodynia activates posterior parietal cortex

N. Witting, MD PhD;, R. C. Kupers, PhD, P. Svensson, DDS Dr.Odont;, L. Arendt–Nielsen;, A. Gjedde, MD and T. S. Jensen, MD

From the Department of Neurology (Dr. Witting and Prof. Jensen), PET center (Dr. Witting and Profs. Kupers and Gjedde), and Danish Pain Research Center (Dr. Witting, Prof. Jensen, and Asst. Prof. Kupers), Aarhus University Hospital; Center for Sensory–Motor Interaction (Dr. Svensson and Prof. Arendt–Nielsen), Aalborg University; and Department of Prosthetic Dentistry and Stomatognathic Physiology (Dr. Svensson), Royal Dental College, Aarhus, Denmark.

Address correspondence and reprint requests to Dr. Nanna Witting, Danish Pain Research Center, Aarhus University Hospital, Building 1A, Noerrebrogade 44, DK-8000 Aarhus C; e-mail: nanna{at}akhphd.au.dk

Objective:— To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET.

Background:— Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. Capsaicin induces both ongoing pain and brush-evoked allodynia.

Methods:— Eight healthy right-handed volunteers participated in eight H215O PET scans with two blocks of four randomized conditions: 1) rest, 2) brush, 3) capsaicin pain, and 4) capsaicin pain + brush (brush-evoked allodynia). Capsaicin was injected intradermally on the nondominant forearm and the subjects rated pain intensity and unpleasantness on 100-mm visual analogue scales.

Results:— Pain intensity and unpleasantness were significantly higher during brush-evoked allodynia (74 ± 4 and 67 ± 4 mm) compared with capsaicin pain alone (60 ± 4 and 51 ± 5 mm). Brush-evoked allodynia, but not capsaicin pain alone, increased blood flow significantly in the contralateral right sensory association cortex Brodmann area (BA) 5/7, and in bilateral prefrontal cortex BA 9/10/47 and insula. No significant activity was seen in thalamus or primary somatosensory cortex (SI). Direct comparison between capsaicin pain and brush-evoked allodynia revealed significant increase in contralateral BA 5/7 only.

Conclusions:— The specific activation of contralateral BA 5/7 indicates that this brain region is important to the processing of brush-evoked allodynia. The involvement of BA 5/7 in brush-evoked allodynia is claimed to reflect multisensory input to this region, its role in conscious pain perception, and its neuroplastic properties.




This article has been cited by other articles:


Home page
 NeurologyHome page
R. Kupers, C. Maihofner, and F. Birklein
Functional imaging of allodynia in complex regional pain syndrome
Neurology, October 24, 2006; 67(8): 1526 - 1526.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Becerra, S. Morris, S. Bazes, R. Gostic, S. Sherman, J. Gostic, G. Pendse, E. Moulton, S. Scrivani, D. Keith, et al.
Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli.
J. Neurosci., October 18, 2006; 26(42): 10646 - 10657.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. Ducreux, N. Attal, F. Parker, and D. Bouhassira
Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia
Brain, April 1, 2006; 129(4): 963 - 976.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. D. Iannetti, L. Zambreanu, R. G. Wise, T. J. Buchanan, J. P. Huggins, T. S. Smart, W. Vennart, and I. Tracey
From The Cover: Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans
PNAS, December 13, 2005; 102(50): 18195 - 18200.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Peyron, F. Schneider, I. Faillenot, P. Convers, F.-G. Barral, L. Garcia-Larrea, and B. Laurent
An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain
Neurology, November 23, 2004; 63(10): 1838 - 1846.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
C. A. Porro
Functional Imaging and Pain: Behavior, Perception, and Modulation
Neuroscientist, October 1, 2003; 9(5): 354 - 369.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by AAN Enterprises, Inc.