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From the Division of Brain Mapping (Dr. Sicotte), Department of Neurology (Drs. Sicotte and Voskuhl), UCLA School of Medicine, Los Angeles, CA.
Address correspondence and reprint requests to Dr. Nancy L. Sicotte, 710 Westwood Boulevard, Rm. A135, Los Angeles, CA 90095; e-mail: nsicotte{at}ucla.edu
Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine implicated in autoimmune disease are effective, especially for rheumatoid arthritis. We report a patient with new onset MS closely associated with the initiation of anti-TNF therapy for juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this individual.
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