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Neurology 2001;57:1888-1890
© 2001 American Academy of Neurology
Brief Communications

Transcallosal bands: A sign of neuronal tract degeneration in early MS?

Jack H. Simon, MD PhD;, Lawrence Jacobs, MD and R. Philip Kinkel, MD

From the Department of Radiology–Neuroradiology (Dr. Simon), University of Colorado Health Sciences Center, Denver; Department of Neurology (Dr. Jacobs), Buffalo General Hospital, NY; and Cleveland Clinic Foundation (Dr. Kinkel), OH.

Address correspondence and reprint requests to Dr. Jack H. Simon, Department of Radiology/MRI, University of Colorado Health Sciences Center, Box A-034, 4200 E. Ninth Avenue, Denver, CO 80262; e-mail: jack.simon{at}uchsc.edu

A pattern of injury observed in patients at high risk for MS described as transcallosal bands (TCB) is hypothesized to be the result of neuronal tract degeneration in earliest MS, extending from typical acute, focal demyelinating lesions located along the lateral borders of the corpus callosum. The TCB, a T2-hyperintense lesion traversing the corpus callosum is recognized on 3-mm thick, T2-weighted imaging, develops over months and persists over years.




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