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Neurology 2001;57:1896-1899
© 2001 American Academy of Neurology
Brief Communications

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy

B. R. Ólafsdóttir, MSc, D. B. Rye, MD PhD;, T. E. Scammell, MD, J. K. Matheson, MD, K. Stefánsson, MD PhD; and J. R. Gulcher, MD PhD

From deCODE genetics Inc. (Drs. Stefánsson and Gulcher, and B. Ólafsdóttir), Reykjavík, Iceland; Department of Neurology (Dr. Rye), Emory University, Atlanta, GA; and Department of Neurology (Drs. Scammell and Matheson), Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA.

Address correspondence and reprint requests to Dr. J.R. Gulcher, deCODE genetics, Lyngháls 1, 110 Reykjavík, Iceland; e-mail: jgulcher{at}decode.is

The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.




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