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Neurology 2001;57:1909-1912
© 2001 American Academy of Neurology
Brief Communications

Antiganglioside antibodies in polyneuropathy associated with monoclonal gammopathy

M. Eurelings, MD, C. W. Ang, MD PhD;, N. C. Notermans, MD PhD;, P. A. Van Doorn, MD PhD;, B. C. Jacobs, MD PhD; and L. H. Van den Berg, MD PhD

From the Department of Neurology (Drs. Eurelings, Notermans, and Van den Berg), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht; and Department of Neurology (Drs. Van Doorn, Ang, and Jacobs), University Hospital Rotterdam, the Netherlands.

Address correspondence and reprint requests to Dr. L.H. Van den Berg, Department of Neurology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; e-mail: l.h.vandenberg{at}neuro.azu.nl

Antibody reactivity to GA1, GM1, GM2, GD1a, GD1b, and GQ1b gangliosides was measured in 87 patients with polyneuropathy associated with monoclonal gammopathy (60 IgM, 25 IgG, 2 IgA) and 42 control patients with monoclonal gammopathy without polyneuropathy (21 IgM, 21 IgG). Of these 87 patients, 30% had anti-myelin-associated glycoprotein antibodies and 15% had antiganglioside antibodies. Antiganglioside antibodies were significantly associated with demyelinating neuropathy and with IgM monoclonal gammopathy. Anti-GD1b and anti-GQ1b antibodies were significantly associated with predominantly sensory ataxic neuropathy.




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