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Neurology 2001;57:1923-1925
© 2001 American Academy of Neurology
Brief Communications

Apolipoprotein E and age at onset of Alzheimer’s disease in African American patients

F.C. Goldstein, PhD, A.V. Ashley, MD, M. Gearing, PhD, J. Hanfelt, PhD, L. Penix, MD, L.J. Freedman, MD PhD; and A.I. Levey, MD PhD

From the Departments of Neurology (Drs. Goldstein, Ashley, Freedman, and Levey) and Pathology (Dr. Gearing), Emory University School of Medicine; Department of Biostatistics (Dr. Hanfelt), Emory University; and the Neuroscience Institute (Dr. Penix), Morehouse School of Medicine, Atlanta, GA.

Address correspondence and reprint requests to Dr. F.C. Goldstein, Department of Neurology, Emory University School of Medicine, 1841 Clifton Road N.E., Atlanta, GA 30329; e-mail: fgoldst{at}emory.edu

The authors examined whether the APOE-{epsilon}4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable AD. The authors found a linear dose effect in which each copy of the {epsilon}4 allele was associated with a 3.6-year earlier onset of AD, indicating a dose-dependent relationship between APOE-{epsilon}4 and age at onset of AD in African Americans.




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[Abstract] [Full Text] [PDF]


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