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Neurology 2001;57:2105-2108
© 2001 American Academy of Neurology
Brief Communications

Cerebellar lesions impair rapid saccade amplitude adaptation

Andreas Straube, MD;, Heiner Deubel, PhD;, Jochen Ditterich, PhD and Thomas Eggert, PhD

From the Department of Neurology (Drs. Straube, Ditterich, and Eggert), Klinikum Grosshadern, and Department of Psychology (Dr. Deubel), Ludwig Maximilians University, Munich, Germany.

Address correspondence and reprint requests to Dr. A. Straube, Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: astraube{at}brain.nefo.med.uni-muenchen.de

Article abstract—— This study investigated whether the cerebellum is essential for rapid saccade adaptation. Saccade adaptation was elicited by 30% backward target steps during the primary saccade. Patients with cerebellar lesions adapted less than normal subjects, but saccade adaptation was most impaired in the group of patients with cerebellar degeneration. As the variability of the saccade gain in patients with cerebellar degeneration did not significantly differ from that in the other patients, the increased variability in motor performance due to a cerebellar lesion cannot alone explain this impaired adaptation.




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