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Right arrow Parkinson's disease/Parkinsonism
Neurology 2001;57:2111-2113
© 2001 American Academy of Neurology
Brief Communications

Motor perseveration is an early sign of Parkinson’s disease

D. Stoffers, MA;, H.W. Berendse, MD, PhD;, J.B. Deijen, PhD and E.C. Wolters, MD, PhD

From the Department of Neurology (Drs. Berendse and Wolters and D. Stoffers), Vrije Universiteit Medical Center; and Department of Clinical Neuropsychology (Dr. Deijen), Vrije Universiteit, Amsterdam, the Netherlands.

Address correspondence and reprint requests to D. Stoffers, Department of Neurology, Vrije Universiteit Medical Center, P.O. box 7057, 1007 MB Amsterdam, the Netherlands; e-mail: d.stoffers{at}vumc.nl

Article abstract—— Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to switch cortical behavioral programs in PD. An impairment of random motor generation appears to be a very early feature of PD.




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