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Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI

From the Institute for Ageing and Health (Drs. Middelkoop, Burton, Lloyd, Paling, Barber, Ballard, McKeith, and O’Brien), University of Newcastle upon Tyne, UK; and the Departments of Neurology and Experimental and Theoretical Psychology (Dr. Middelkoop and W. van der Flier), Leiden University Medical Centre, the Netherlands.

Address correspondence and reprint requests to Prof. John O’Brien, Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK; e-mail: j.t.o'brien{at}ncl.ac.uk

Article abstract—— Dementia with Lewy bodies (DLB) is associated with occipital changes in blood flow and metabolism, but structural changes in this region have not previously been assessed. The authors performed volumetric MRI measurement of the occipital lobe blind to the diagnosis in 23 subjects with DLB, 25 with AD, and 24 age-matched control subjects. There were no significant differences between groups in occipital lobe volume. The authors conclude gross structural changes in the occipital lobe do not occur in patients with mild to moderate DLB or AD.

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