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Neurology 2001;57:2120-2122
© 2001 American Academy of Neurology
Brief Communications

Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

T. O. Videen, PhD;, A. R. Zazulia, MD;, E. M. Manno, MD;, C. P. Derdeyn, MD;, R. E. Adams, MD;, M. N. Diringer, MD and W. J. Powers, MD

From the Department of Neurology and Neurological Surgery (Drs. Videen, Zazulia, Manno, Diringer, and Powers), Mallinckrodt Institute of Radiology (Drs. Videen, Derdeyn, and Powers), Neurology–Neurosurgery Intensive Care Unit (Dr. Diringer), and the Lillian Strauss Institute for Neuroscience of the Barnes–Jewish Hospital of St. Louis (Dr. Powers), Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. Tom Videen, East Building Imaging Center, Campus Box 8225, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110; e-mail: tom{at}npg.wustl.edu

Article abstract—— Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential T1-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 ± 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 ± 0.4%) than in the infarcted hemisphere (0.0 ± 0.5%, p < 0.05).




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