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Neurology 2001;57:2122-2125
© 2001 American Academy of Neurology
Brief Communications

Thrombolytic therapy in acute ischemic stroke patients with cardiac thrombus

L. Derex, MD;, N. Nighoghossian, MD;, M. Perinetti, MD;, J. Honnorat, MD and P. Trouillas, MD, PhD

From the Service d’Urgences Neurovasculaires (Drs. Derex, Nighoghossian, Honnorat, and Trouillas), Hôpital Neurologique; and the Laboratoire d’Echocardiographie (Dr. Perinetti), Hôpital Cardiologique, Lyon, France.

Address correspondence and reprint requests to Dr. Laurent Derex, Service d’Urgences Neurovasculaires, Hôpital Neurologique Pierre Wertheimer, 59, Boulevard Pinel, 69003 Lyon, France; e-mail: lderex{at}yahoo.com

Article abstract—— The authors describe the outcome of five patients with a cardiac thrombus selected among 183 patients with stroke (2.7 %) who were given IV tissue plasminogen activator (tPA). No early systemic or cerebral embolism occurred. Two patients made a complete recovery at 3 months. Two patients had a moderate outcome. One patient had late recurrent cerebral embolism and died. These data suggest that the presence of a cardiac thrombus is not associated with a high risk of recurrent embolism in patients with stroke who are given IV tPA.




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