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Neurology 2001;57:2125-2128
© 2001 American Academy of Neurology
Brief Communications

Thrombolysis in patients with transient neurologic deficits

P. Lyden, MD;, M. Lu, PhD;, T. Kwiatkowski, MD;, M. Frankel, MD;, S. Levine, MD;, J. Broderick, MD;, T. Brott, MD and the NINDS rt-PA Stroke Study Group

From the Department of Neurosciences (Dr. Lyden), UCSD School of Medicine, San Diego; the Department of Neurology (Dr. Lyden), Veterans Administration Medical Center, San Diego, CA; Department of Biostatistics & Epidemiology (Dr. Lu), Henry Ford Health System, Detroit; Department of Emergency Medicine (Dr. Kwiatkowski), Long Island Jewish Medical Center, New Hyde Park, NY; Department of Neurology (Dr. Frankel), Emory University School of Medicine, Atlanta, GA; Department of Neurology (Dr. Levine), Wayne State University School of Medicine, Detroit, MI; Department of Neurology (Dr. Broderick), University of Cincinnati School of Medicine, OH; and Mayo Clinic (Dr. Brott), Jacksonville, FL.

Address correspondence and reprint requests to Dr. Patrick Lyden (127), 3350 La Jolla Village Drive, San Diego, CA 92161; e-mail: plyden{at}ucsd.edu

Article abstract—— What is the risk of thrombolysis in patients with acute stroke who might recover without treatment? In the National Institute of Neurological Disorders and Stroke rt-PA for Acute Stroke Trial, 2.6% of patients taking placebo showed spontaneous 24-hour recovery, compared to 11.5% of recombinant tissue-type plasminogen activator (rt-PA)–treated patients (p < 0.001). There were no symptomatic ICH in the patients taking placebo; one hypertensive, rt-PA–treated patient hemorrhaged. Assuming the National Institute of Neurological Disorders and Stroke protocol is followed rigorously, patients with acute stroke rarely recover spontaneously and the thrombolytic risk is low.




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A. Kobayashi, M. Skowronska, T. Litwin, and A. Czlonkowska
Lack of experience of intravenous thrombolysis for acute ischaemic stroke does not influence the proportion of patients treated
Emerg. Med. J., February 1, 2007; 24(2): 96 - 99.
[Abstract] [Full Text] [PDF]


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