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Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke:

A pilot study

From the Neurologische Abteilung, Stroke Unit, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.

Address correspondence and reprint requests to Dr. Hans–Christian Koennecke, Department of Neurology, Evangelisches Krankenhaus Königin Elisabeth Herzberge, Herzbergstrasse 79, 10362 Berlin, Germany; e-mail: h.koennecke{at}keh-berlin.de

Fever is associated with poor outcome in acute stroke. Forty-two consecutive, normothermic patients with acute ischemic stroke were, within 24 hours from symptom onset, randomized to either receive 4 g acetaminophen daily (n = 20) or matched placebo (n = 22). Fever of greater than 37.5 °C occurred in 36.4% of patients in the placebo group, compared with 5.0% in the acetaminophen group (Fisher’s exact test, p = 0.014). Prophylactic antipyretic treatment with acetaminophen may be effective in the prevention of fever after acute ischemic stroke.

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