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Neurology 2001;57:2307-2310
© 2001 American Academy of Neurology
Brief Communications

Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

M. O’Sullivan, MRCP, P. E. Summers, PhD, D. K. Jones, PhD, J. M. Jarosz, FRCR, S. C.R. Williams, PhD and H. S. Markus, FRCP

From the Division of Clinical Neuroscience (Dr. O’Sullivan and H.S. Markus), St. George’s Hospital Medical School, and the Department of Neuroimaging (Drs. Summers and Williams, and J.M. Jarosz) and Section of Old Age Psychiatry (Dr. Jones), Institute of Psychiatry, London, UK.

Address correspondence and reprint requests to Dr. Mike O’Sullivan, Division of Clinical Neuroscience, St. George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK; e-mail: m.osullivan{at}sghms.ac.uk

Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly with cognitive dysfunction. Diffusion tensor MRI may provide better markers of tract integrity. Changes in the normal-appearing white matter were demonstrated in 30 patients with ischemic leukoaraiosis compared with 17 age-matched control subjects. These changes correlated with executive dysfunction assessed by the Wisconsin Card Sorting Test.




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