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 Volume 57, Number 2, July 24, 2001
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Neurology 2001;57:321-324
© 2001 American Academy of Neurology
Brief Communications

Is carbamazepine teratogenic?

A prospective controlled study of 210 pregnancies

Orna Diav-Citrin, MD;, Svetlana Shechtman, PhD;, Judy Arnon, PhD and Asher Ornoy, MD

From the Israeli Teratogen Information Service (Drs. Diav-Citrin, Shechtman, Arnon, and Ornoy), Laboratory of Teratology; Department of Anatomy and Cell Biology (Dr. Ornoy), Hebrew University, Hadassah Medical School; and Israeli Ministry of Health (Drs. Diav-Citrin, Shechtman, Arnon, and Ornoy), Jerusalem, Israel.

Address correspondence and reprint requests to Dr. Asher Ornoy, Department of Anatomy and Cell Biology, Hebrew University and Hadassah Medical School, PO Box 12272, Jerusalem, 91120, Israel.

The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1–4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.




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