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Increased von Willebrand factor in migraine

From the Department of Neurology, Department of Medicine, Medical College of Ohio, Toledo.

Address correspondence and reprint requests to Dr. Gretchen E. Tietjen, 3120 Glendale Ave., Toledo, OH 43614; e-mail: gtietjen{at}mco.edu

The authors determined von Willebrand factor (vWF) in 63 persons with migraine, 11 persons with migraine and prior stroke, and 35 frequency-matched controls. Additional studies were done in a subset with migraine without aura who were headache free for >7 days. Migraineurs with prior stroke had significantly higher vWF antigen (170% versus 106%) and activity (162% versus 108%) than the control group. vWF antigen (126%) and activity (130%) were also significantly higher in migraineurs without stroke. Multimers and protease activity were normal in the interictal subset.

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