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Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer’s disease

From the Third Department of Internal Medicine (Drs. Maruyama, Izumi, Oda, Torii, Morino, Toji, Nakamura, and Kawakami), Hiroshima University School of Medicine; Kinoko Espoir Hospital (Dr. Sasaki), Kasaoka, Okayama; and Department of Neurology (Dr. Terasawa), Sumitomo Hospital, Osaka, Japan.

Address correspondence and reprint requests to Dr. Hideshi Kawakami, Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan; e-mail: hkawakam{at}ipc.hiroshima-u.ac.jp

Associations between polymorphisms of the cystatin C gene (CST3) at 5' flanking region and exon 1 in Caucasian patients with late onset AD and exon 1 in a US study of late onset AD have been reported. Clinically diagnosed Japanese patients with AD and Japanese normal control subjects were assessed for the presence of polymorphisms of CST3. The authors could not confirm the previously reported association between CST3 polymorphisms and AD in Japan. Age had no effect on the CST3 genotype.

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