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Right arrow Amyotrophic lateral sclerosis
Neurology 2001;57:357-359
© 2001 American Academy of Neurology
Brief Communications

Postural change of forced vital capacity predicts some respiratory symptoms in ALS

J. Varrato, DO;, A. Siderowf, MD;, P. Damiano, RN;, S. Gregory, MD;, D. Feinberg, MD; and L. McCluskey, MD

From the Department of Neurology (Drs. Varrato, Siderowf, Feinberg, and McClusky, and P. Damiano), University of Pennsylvania; and the Department of Medicine (Dr. Gregory), Pennsylvania Hospital, Philadelphia.

Address correspondence and reprint requests to Dr. Leo McCluskey, Penn Neurological Institute, 330 South 9th Street, Philadelphia, PA 19107; e-mail: lfmcclusky{at}pahosp.com

The detection of respiratory muscle weakness in ALS is necessary to plan initiation of noninvasive positive pressure ventilation and begin discussion of advanced directives. The authors measured the erect seated and supine forced vital capacity (FVC) in 38 patients with ALS and 15 controls. The supine FVC is significantly lower and the erect - supine FVC difference is significantly greater in patients with complaints of dyspnea, orthopnea, and daytime fatigue.




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