| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Division of Biostatistics and Epidemiology (Dr. Abbott), University of Virginia School of Medicine, Charlottesville; Pacific Health Research Institute (Drs. Abbott, Petrovitch, White, Masaki, Curb, and Ross), Honolulu; Kuakini Medical Center and the Honolulu–Asia Aging Study (Drs. Abbott, Petrovitch, White, Masaki, Curb, Blanchette, Popper, and Ross), Honolulu; Department of Medicine (Drs. Abbott, Petrovitch, White, Masaki, Curb, Blanchette, and Ross) and the Pacific Biomedical Research Center (Dr. Grandinetti), University of Hawaii John A. Burns School of Medicine, Honolulu; Parkinson’s Institute (Drs. Tanner and Ross), Sunnyvale, CA; and the Department of Veterans Affairs (Drs. Petrovitch, White, and Ross), Honolulu, HI.
Address correspondence and reprint requests to Dr. Robert D. Abbott, Pacific Health Research Institute, 846 South Hotel Street, Suite 303, Honolulu, HI 96813-2512; e-mail: rda3e{at}virginia.edu
Background:— Constipation is frequent in PD, although its onset in relation to clinical PD has not been well described. Demonstration that constipation can precede clinical PD could provide important clues to understanding disease progression and etiology. The purpose of this report is to examine the association between the frequency of bowel movements and the future risk of PD.
Methods:— Information on the frequency of bowel movements was collected from 1971 to 1974 in 6790 men aged 51 to 75 years without PD in the Honolulu Heart Program. Follow-up for incident PD occurred over a 24-year period.
Results:— Ninety-six men developed PD an average of 12 years into follow-up. Age-adjusted incidence declined consistently from 18.9/10,000 person-years in men with <1 bowel movement/day to 3.8/10,000 person-years in those with >2/day (p = 0.005). After adjustment for age, pack-years of cigarette smoking, coffee consumption, laxative use, jogging, and the intake of fruits, vegetables, and grains, men with <1 bowel movement/day had a 2.7-fold excess risk of PD versus men with 1/day (95% CI: 1.3, 5.5; p = 0.007). The risk of PD in men with <1 bowel movement/day increased to a 4.1-fold excess when compared with men with 2/day (95% CI: 1.7, 9.6; p = 0.001) and to a 4.5-fold excess versus men with >2/day (95% CI: 1.2, 16.9; p = 0.025).
Conclusions:— Findings indicate that infrequent bowel movements are associated with an elevated risk of future PD. Further study is needed to determine whether constipation is part of early PD processes or is a marker of susceptibility or environmental factors that may cause PD.
This article has been cited by other articles:
|
|
 |
|
  T. N. Taylor, W. M. Caudle, K. R. Shepherd, A. Noorian, C. R. Jackson, P. M. Iuvone, D. Weinshenker, J. G. Greene, and G. W. Miller Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity J. Neurosci., June 24, 2009; 29(25): 8103 - 8113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Olanow, M. B. Stern, and K. Sethi The scientific and clinical basis for the treatment of Parkinson disease (2009) Neurology, May 26, 2009; 72(21_Supplement_4): S1 - S136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tolosa, C. Gaig, J. Santamaria, and Y. Compta Diagnosis and the premotor phase of Parkinson disease Neurology, February 17, 2009; 72(7_Supplement_2): S12 - S20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Lim, S. H. Fox, and A. E. Lang Overview of the Extranigral Aspects of Parkinson Disease Arch Neurol, February 1, 2009; 66(2): 167 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. PANDYA, C. S. KUBU, and M. L. GIROUX Parkinson disease: Not just a movement disorder Cleveland Clinic Journal of Medicine, December 1, 2008; 75(12): 856 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Braak and K. Del Tredici Invited Article: Nervous system pathology in sporadic Parkinson disease Neurology, May 13, 2008; 70(20): 1916 - 1925. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Gao, H. Chen, M. A. Schwarzschild, D. B. Glasser, G. Logroscino, E. B. Rimm, and A. Ascherio Erectile Function and Risk of Parkinson's Disease Am. J. Epidemiol., December 15, 2007; 166(12): 1446 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Ahlskog Beating a dead horse: Dopamine and Parkinson disease Neurology, October 23, 2007; 69(17): 1701 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Shannon Dopamine: So "last century" Neurology, July 24, 2007; 69(4): 329 - 330. [Full Text] [PDF]
|
|
|
|
|
|
D. Verbaan, J. Marinus, M. Visser, S. M. van Rooden, A. M. Stiggelbout, and J. J. van Hilten Patient-reported autonomic symptoms in Parkinson disease Neurology, July 24, 2007; 69(4): 333 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Minguez-Castellanos, C. E. Chamorro, F. Escamilla-Sevilla, A. Ortega-Moreno, A. C. Rebollo, M. Gomez-Rio, A. Concha, and D. G. Munoz Do {alpha}-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: A cohort study Neurology, June 5, 2007; 68(23): 2012 - 2018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Lang The progression of Parkinson disease: A hypothesis Neurology, March 20, 2007; 68(12): 948 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H Hawkes and J. Deeb Predicting Parkinson's disease: worthwhile but are we there yet? Practical Neurology, October 1, 2006; 6(5): 272 - 277. [Full Text] [PDF]
|
|
|
|
|
|
W. Poewe The need for neuroprotective therapies in Parkinson's disease: A clinical perspective Neurology, May 23, 2006; 66(10_suppl_4): S2 - S9. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Abbott, G. W. Ross, L. R. White, C. M. Tanner, K. H. Masaki, J. S. Nelson, J. D. Curb, and H. Petrovitch Excessive daytime sleepiness and subsequent development of Parkinson disease Neurology, November 8, 2005; 65(9): 1442 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kaufmann, K. Nahm, D. Purohit, and D. Wolfe Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies Neurology, September 28, 2004; 63(6): 1093 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Sakakibara, T Odaka, T Uchiyama, M Asahina, K Yamaguchi, T Yamaguchi, T Yamanishi, and T Hattori Colonic transit time and rectoanal videomanometry in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, February 1, 2003; 74(2): 268 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Lesser, R. D. Abbott, and H. Petrovitch Frequency of bowel movements and future risk of Parkinson's disease Neurology, March 12, 2002; 58(5): 838 - 839. [Full Text] [PDF]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
