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Neurology 2001;57:539-541
© 2001 American Academy of Neurology
Brief Communications

Narcolepsy associated with other central nervous system disorders

Syed Malik, MD;, Bradley F. Boeve, MD;, Lois E. Krahn, MD; and Michael H. Silber, MB, ChB

From the Sleep Disorders Center (Drs. Malik, Boeve, and Krahn and M.H. Silber) and the Departments of Neurology (Dr. Boeve and M.H. Silber) and Psychiatry (Dr. Krahn), Mayo Clinic, Rochester, MN., Dr. Malik is currently affiliated with the Sleep Disorders Center and Division of Pulmonology, Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Dr. M.H. Silber, Department of Neurology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905; e-mail: msilber{at}mayo.edu

The authors identified patients with the coexistence of narcolepsy and another CNS disorder seen between 1975 and 1998 at their institution. Eighteen patients were identified, nine with narcolepsy commencing within 1 year before or after the other disorder. Seven patients (39%) had hypothalamic–pituitary syndromes. When they occur together, narcolepsy and other CNS disorders frequently emerge at about the same time, suggesting a causative relationship. Hypothalamic–pituitary pathology was the most common association.




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