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Neurology 2001;57:542-544
© 2001 American Academy of Neurology
Brief Communications

CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowing

N. Sacktor, MD;, P. M. Tarwater, PhD;, R. L. Skolasky, MA;, J. C. McArthur, MB, BS, MPH;, O. A. Selnes, PhD;, J. Becker, PhD;, B. Cohen, MD;, E. N. Miller, PhD; and for the Multicenter AIDS Cohort Study (MACS)*

From the Department of Neurology (Drs. Sacktor and Selnes and J.C. McArthur), Johns Hopkins University School of Medicine, and the Department of Epidemiology (Dr. Tarwater and J.C. McArthur and R.L. Skolasky), Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; Neuropsychology Research Program (Dr. Becker), University of Pittsburgh Medical Center, Pittsburgh, PA; Department of Neurology (Dr. Cohen), Northwestern University, Chicago, IL; and Neuropsychiatric Institute (Dr. Miller), University of California, Los Angeles, CA.

Address correspondence and reprint requests to Dr. N. Sacktor, Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave., B-Building, Room 122, Baltimore, MD 21224; e-mail: sacktor{at}jhmi.edu

The authors evaluated whether highly active antiretroviral therapy (HAART) with multiple CSF-penetrating drugs results in greater improvement in HIV-associated psychomotor slowing than HAART with a single CSF-penetrating drug. Both groups had improvement in CD4 count, plasma viral load, as well as two tests of psychomotor speed. Comparing the two groups, there were no differences in the mean change for CD4 count, viral load, or any of the neuropsychological tests. Multiple and single CSF-penetrating HAART may be equivalent for treating HIV-associated psychomotor slowing.




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