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Prevalence and correlates of parkinsonism in patients with primary depression

From the Departments of Neuropsychiatry (Drs. Starkstein, Petracca, and Chemerinski) and Neurology (Drs. Starkstein and Merello), Raúl Carrea Institute of Neurological Research–FLENI, Buenos Aires, Argentina.

Address correspondence and reprint requests to Dr. S.E. Starkstein, FLENI, Montañeses 2325, 1428 Buenos Aires, Argentina; e-mail: ses{at}fleni.org.ar

The authors examined the prevalence, clinical correlates, and longitudinal changes of parkinsonism in 94 patients with primary depression and 20 healthy control subjects. Parkinsonism was present in 20% of patients with primary depression. This syndrome was significantly associated with older age, more severe depression, and more severe cognitive impairment. In a subgroup of depressed patients, parkinsonism was reversible upon recovery from the mood disorder.