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Prolonged cortical silent period after transcranial magnetic stimulation in generalized epilepsy

From the Department of Neurology, Austin and Repatriation Medical Centre (Drs. Macdonell, King, Curatolo, Reutens, and Berkovic), Heidelberg; and Department of Medicine (Drs. Macdonell, King, Reutens, and Berkovic), University of Melbourne, Victoria, Australia.

Address correspondence and reprint requests to Dr. R.A.L. Macdonell, Department of Neurology, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, Victoria 3084, Australia; e-mail: rmac{at}austin.unimelb.edu.au

Transcranial magnetic stimulation (TMS) produces a cortical silent period (CSP) during a voluntary contraction. The duration of the CSP was used to assess the level of intracortical inhibition in patients with untreated idiopathic generalized epilepsy (IGE). Mean CSP duration was assessed at three TMS stimuli in 21 patients with IGE compared with 19 normal control subjects. Mean CSP duration was increased at all stimulus intensities, indicating that intracortical inhibition is increased in patients with IGE.

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