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From Dalhousie University (Drs. Wentzel, Rockwood, and MacKnight), Halifax, Nova Scotia; University of Western Ontario (Dr. Hachinski), London; University of Calgary (Dr. Hogan), Alberta; University of British Columbia (Dr. Feldman), Vancouver; McGill University (Drs. Wolfson and Gauthier), Montréal, Quebéc; Université Laval (Dr. Verreault), Quebéc City, Quebéc; University of Ottawa (Dr. McDowell), Ontario, Canada; and Duke University Medical Center (Dr. Østbye), Durham, NC.
Address correspondence and reprint requests to Dr. Kenneth Rockwood, Division of Geriatric Medicine, Dalhousie University, QEII Health Sciences Centre, 5955 Jubilee Road, Room 1421 VMB, Halifax, Nova Scotia, Canada B3H 2E1; e-mail: Kenneth.Rockwood{at}Dal.Ca
Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 ± 6.7 years; 61% women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.
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