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Neurology 2001;57:719-722
© 2001 American Academy of Neurology
Brief Communications

Response to cancer therapy in a patient with a paraneoplastic choreiform disorder

David Croteau, MD, FRCP(C);, Alaa Owainati, MD, PhD;, Josep Dalmau, MD, PhD; and Lisa R. Rogers, DO

From the Departments of Neurosurgery (Drs. Croteau and Rogers) and Neurology (Dr. Rogers), Henry Ford Hospital, Detroit; and Department of Medical Oncology (Dr. Owainati), Oakland Medical Center, Pontiac, MI; and Department of Neurology (Dr. Dalmau), University of Arkansas for Medical Sciences, Little Rock.

Address correspondence and reprint requests to Dr. L.R. Rogers, Department of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202.

The authors report a patient with chorea and multifocal neurologic abnormalities associated with a small-cell lung carcinoma. A previously unreported antibody directed at a 76-kD neuronal protein antigen was identified in both serum and CSF. Antitumor treatment resulted in dramatic and sustained clinical neurologic and serologic responses.




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