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 Volume 57, Number 4, August 28, 2001
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Neurology 2001;57:736-738
© 2001 American Academy of Neurology
Brief Communications

Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: Evidence of molecular mimicry

Susumu Kusunoki, MD;, Meiko Shiina, MD; and Ichiro Kanazawa, MD

From the Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan.

Address correspondence and reprint requests to Dr. Susumu Kusunoki, Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; e-mail: kusunoki-tky{at}umin.ac.jp

The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain–Barré syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.




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