Neurology 2001;57:755-761
© 2001 American Academy of Neurology
Views & Reviews
DNA microarray gene expression analysis technology and its application to neurological disorders
Steven A. Greenberg, MD
From the Department of Neurology, Neuromuscular Division, Brigham and Women’s Hospital, and the Children’s Hospital Informatics Program, Children’s Hospital, Harvard Medical School, Boston, MA.
Address correspondence and reprint requests to Dr. Steven A. Greenberg, Department of Neurology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115; e-mail: sagreenberg{at}partners.org
DNA microarray technology is currently an area of great interest. Also called "genechip" technology, it incorporates molecular genetics and computer science on a massive scale. This technology can rapidly provide a detailed view of the simultaneous expression of entire genomes and provide new insights into gene function, disease pathophysiology, disease classification, and drug development. In this review, the author discusses the basic theory behind genechip and other biologic chip technologies, their limitations given the current state of biologic knowledge and computational abilities, and their potential applications to the understanding of neurologic disorders.
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