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Neurology 2001;57:920-924
© 2001 American Academy of Neurology
Brief Communications

Objective assessment of progression in Huntington’s disease: A 3-year follow-up study

R. Reilmann, MD;, F. Kirsten, BSc;, L. Quinn, EdD, PT;, H. Henningsen, MD;, K. Marder, MD, MPH; and A. M. Gordon, PhD

From the Department of Biobehavioral Sciences (Drs. Reilmann and Gordon, and F. Kirsten), Teachers College, and Department of Rehabilitation Medicine (Drs. Reilmann and Gordon) and Department of Neurology and The Sergievsky Center and The Taub Institute (Dr. Marder), College of Physicians and Surgeons, Columbia University, New York, NY; Program in Physical Therapy (Dr. Quinn), Graduate School of Health Sciences, New York Medical College, Valhalla, NY; and Department of Neurology (Dr. Henningsen), Westfälische Wilhelms-University, Münster, Germany.

Address correspondence and reprint requests to Dr. Andrew Gordon, Department of Biobehavioral Sciences, Columbia University Teachers College, Box 199, 525 W. 120th Street, New York, NY 10027; e-mail: ag275{at}columbia.edu

Objective measures to assess progression of Huntington’s disease (HD) are desirable. The authors have previously found that patients with HD with higher Unified Huntington’s Disease Rating Scale (UHDRS) motor scores exhibited higher variability of isometric grip forces while grasping an object. Therefore, the authors assessed grip force variability during this task in 10 HD patients with a 3-year follow-up. Grip force variability increased in all patients at the follow-up. Thus, grip force variability during grasping might be an objective and quantitative measure to assess motor deficits associated with the progression of HD.




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