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Neurology 2001;57:930-932
© 2001 American Academy of Neurology
Brief Communications

Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

F. Jessen, MD*;, W. Block, PhD*;, F. Träber, PhD;, E. Keller, MD;, S. Flacke, MD, PhD;, R. Lamerichs, PhD;, H. H. Schild, MD; and R. Heun, MD, PhD

From the Departments of Psychiatry (Drs. Jessen and Heun) and Radiology (Drs. Block, Träber, Keller, Flacke, and Schild), University of Bonn, Germany; and Philips Medical Systems (Dr. Lamerichs), Best, The Netherlands.

Address correspondence and reprint requests to Dr. Frank Jessen, Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany; e-mail: jessen{at}uni-bonn.de

In this 1H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.




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