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From the Departments of Neuroradiology (Drs. Lehéricy, Poupon, and Marsault), Neurology (Dr. Agid), and INSERM U289 (Drs. Vidailhet and Agid), Hôpital de la Pitié-Salpêtrière; Department of Neurology (Dr. Vidailhet), Hôpital Saint Antoine, Paris; and Departments of Neurology (Drs. Pollak and Limousin) and Magnetic Resonance (Drs. Grand and Le Bas), University Hospital, Grenoble, France.
Address correspondence and reprint requests to Dr. S. Lehéricy, Service de Neuroradiologie, Bâtiment Babinski, Hôpital de la Salpêtrière, 47 bd de l’Hôpital, 75856 Paris Cedex, France; e-mail: stephane.lehericy{at}psl.ap-hop-paris.fr
Objective:— To determine which thalamic subnuclei are involved in symptomatic unilateral movement disorders due to localized thalamic infarction, and the clinical characteristics of these abnormal movements.
Methods:— The authors studied 22 patients with thalamic infarcts for their clinical presentation and the topography of the lesions, using three-dimensional T1-weighted MRI sequencing and stereotaxic analysis of the lesions.
Results:— Patients were divided into four groups: 1) absence of abnormal involuntary movements (AIM) (nine patients); 2) isolated dystonic posture (two patients); 3) myoclonic dystonia (five patients); and 4) tremor or myoclonus (six patients). In patients with AIM, thalamic lesions were contralateral to the abnormal movements, involving the thalamogeniculate territory, centered on the ventral intermediate (Vim) and ventral caudal (Vc) nuclei. No significant difference in the volumes or center of mass of the lesions was found between patients with tremor and myoclonus and patients with dystonia, although the central nucleus and the internal part of the Vim nucleus were more consistently damaged in dystonic patients.
Conclusion:— Movement disorders related to thalamic lesions included: 1) myoclonic dystonia with predominating myoclonus and "thalamic" hand associating dystonic posture and slow, pseudo-athetoid movements, both related to lesions in the Vim and Vc nuclei of the thalamus; and 2) postural and action tremor, also related to lesions in the Vim, similar to tremor associated with midbrain lesions, as a result of abnormal functioning of the cerebello-thalamic pathways.
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