Neurology 2001;57:1094-1097
© 2001 American Academy of Neurology
Brief Communications
An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy
D.J.L. MacGowan, MD MRCPI;,
S.N. Scelsa, MD and
M. Waldron, MD
From the Departments of Neurology (Drs. MacGowan and Scelsa) and Infectious Diseases (Dr. Waldron), Beth Israel Medical Center, New York, NY.
Address correspondence and reprint requests to Dr. D.J.L. MacGowan, Department of Neurology, Beth Israel Medical Center, 10 Union Square East, Suite 2Q, New York, NY 10003; e-mail: dmacgow{at}bethisraelny.org
A 32-year-old woman presenting with a rapidly progressive ALS-like syndrome was found to be HIV positive with a CD4 count of 44/mm3. The patient recovered completely during 1 year after treatment with nelfinavir, zidovudine, and lamivudine, and recovery is sustained nearly 4 years later. Recovery was accompanied by HIV RNA becoming undetectable in plasma and CSF.
This article has been cited by other articles:

|
 |

|
 |
 
F Henning and R H Hewlett
Brachial amyotrophic diplegia (segmental proximal spinal muscular atrophy) associated with HIV infection
J. Neurol. Neurosurg. Psychiatry,
December 1, 2008;
79(12):
1392 - 1394.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. L. McCormick, R. H. Brown Jr, M. E. Cudkowicz, A. Al-Chalabi, and J. A. Garson
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
Neurology,
January 22, 2008;
70(4):
278 - 283.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D.J.L. MacGowan, S. N. Scelsa, T. E. Imperato, K.-N Liu, P. Baron, and B. Polsky
A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS
Neurology,
May 29, 2007;
68(22):
1944 - 1946.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. R. Berger, P. S. Espinosa, and J. Kissel
Brachial Amyotrophic Diplegia in a Patient With Human Immunodeficiency Virus Infection: Widening the Spectrum of Motor Neuron Diseases Occurring With the Human Immunodeficiency Virus
Arch Neurol,
May 1, 2005;
62(5):
817 - 823.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. N. Scelsa, D. J.L. MacGowan, H. Mitsumoto, T. Imperato, A. J. LeValley, M. H. Liu, M. DelBene, and M. Y. Kim
A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS
Neurology,
April 12, 2005;
64(7):
1298 - 1300.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. J. Steele, A. Al-Chalabi, K. Ferrante, M. E. Cudkowicz, R. H. Brown Jr., and J. A. Garson
Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives
Neurology,
February 8, 2005;
64(3):
454 - 458.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Corcia, H.-F. Jafari-Schluep, D. Lardillier, H. Mazyad, P. Giraud, P. Clavelou, J. Pouget, and W. Camu
A Clustering of Conjugal Amyotrophic Lateral Sclerosis in Southeastern France
Arch Neurol,
April 1, 2003;
60(4):
553 - 557.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. A. Cone, R. Nazemi, M. O. Cone, H.J. V. Giesen, R. Kaiser, H. Koller, K. Wetzel, G. Arendt, A. Moulignier, and D. MacGowan
Reversible ALS-like disorder in HIV infection An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy
Neurology,
August 13, 2002;
59(3):
474 - 475.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Jubelt and J. R. Berger
Does viral disease underlie ALS?: Lessons from the AIDS pandemic
Neurology,
September 25, 2001;
57(6):
945 - 946.
[Full Text]
[PDF]
|
 |
|
Correspondence:
Read all Correspondence
- An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy
- Lawrence A Cone
- Neurology Online, 15 Mar 2002
[Full text]
- An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy
- H J v Giesen, et al.
- Neurology Online, 15 Mar 2002
[Full text]
- Reply to both Letters to the Editor
- Daniel Mac Gowan
- Neurology Online, 15 Mar 2002
[Full text]
|