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Neurology 2001;57:1100-1103
© 2001 American Academy of Neurology
Brief Communications

Intra-arterial urokinase for acute ischemic stroke

Factors associated with complications

D.L. Tirschwell, MD MSc;, W.M. Coplin, MD, K.J. Becker, MD, P. Vogelzang, MD, J. Eskridge, MD, D. Haynor, MD, W. Cohen, MD, D. Newell, MD, H.R. Winn, MD and W.T. Longstreth, Jr., MD MPH

From the Departments of Neurology (Drs. Tirschwell, Becker, and Longstreth), Neuroradiology (Drs. Eskridge, Haynor, and Cohen), Neurological Surgery (Drs. Becker, Eskridge, Newell, and Winn), and Epidemiology (Dr. Longstreth), University of Washington, Seattle; Seattle Radiologists (Dr. Vogelzang); and the Departments of Neurology and Neurosurgery (Dr. Coplin), Wayne State University, Detroit, MI.

Address correspondence and reprint requests to Dr. David Tirschwell, 325 Ninth Ave., Box 359775, Seattle, WA 98104-2499; e-mail: tirsch{at}u washington.edu

The authors abstracted the records of 43 patients treated with intra-arterial urokinase for acute ischemic stroke to identify predictors of serious complications. Sixteen (37%) had such a complication. Higher urokinase dose (>1.5 x 106 U), higher mean arterial blood pressure before treatment (>130 mm Hg), basilar occlusive strokes, and severe strokes were most predictive of these complications. Although urokinase is no longer manufactured, these findings identify patients at risk for complications from other intra-arterial thrombolytics.






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