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Neurology 2001;57:1115-1118
© 2001 American Academy of Neurology
Brief Communications

1H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia

C. Mañeru, MS, C. Junqué, PhD, N. Bargalló, MD, M. Olondo, MD, F. Botet, MD, M. Tallada, MD, J. Guardia, PhD and J. M. Mercader, MD

From the Department of Psychiatry and Clinical Psychobiology (Drs. Mañeru and Junqué) and the Hospital Clinic, Faculty of Medicine (Dr. Botet), University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Service of Neuroradiology (Drs. Bargalló, Olondo, and Mercader), Hospital Clinic, Faculty of Medicine, University of Barcelona; Services of Neurophysiology and Neurology (Dr. Tallada), Vall d’Hebron Children Hospital, Barcelona; and Department of Methodology and Behavioural Sciences (Dr. Guardia), University of Barcelona, Spain.

Address correspondence and reprint requests to Dr. C. Junqué at Departament de Psiquiatria i Psicobiologia Clínica, IDIBAPS, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain; e-mail: cjunque{at}psi.ub.es

The authors performed neuropsychological and 1H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and reduced NAA/choline values in the MTR. Neuropsychological testing showed group differences in tasks related to attention and memory. These results indicate persistent dysfunctions in cerebral structures vulnerable to hypoxia and demonstrate the utility of MRS for the long-term evaluation of cerebral sequelae of neonatal asphyxia.




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